Biotechnology is one of the rapidly growing 21th century technology which supports discovery and innovation to alleviate the challenges in health, agriculture, food processing, industry and environmental sectors. Biotechnology is defined as any technological application that uses biological systems, living organisms or parts thereof to make, modify products or processes for the benefits of human kind. The estimated world population in 2050 is 9.1 billion. The research did to feed this rapidly growing populations are not as rapid as the rate of population growth. Therefore the agricultural biotechnology would have a rapid solution to the challenges faced to increase agricultural production.  Currently different biotechnological tools have different solutions for, different type of climate change that is happening due to human made activity and different type of acute and chronic diseases that spreads in different continents of the world.  In developing country like Ethiopia, the potential application of biotechnology is yet underutilized due to lack of trained manpower, facility and government policy support in biotechnology. Hence, biotechnology program launched in Wolkite Universities, Ethiopia to produce competent graduates who will be able to understand the potentials, and impact of biotechnological solutions on agriculture, industry, health, environment and societal context.